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The goal of this review would be to characterize the metabolites of EAM-2201 in human hepatocytes acquired in vitro and those in liver and urine specimens received in vivo within the autopsy here of the EAM-2201 abuser.
Twelve metabolites of the synthetic cannabinoid, EAM-2201, have been tentatively recognized in human hepatocytes in vitro, As well as in human liver and urine specimens in vivo for The 1st time. There was a distinct big difference in metabolism profile in between the in vitro As well as in vivo effects.
EAM-2201 was incubated with human hepatocytes for three h in the CO2 incubator as well as the metabolites of EAM-2201 were generated. The human liver specimen was homogenized as well as the metabolites were extracted. The urine specimen was hydrolyzed 1st with β-glucuronidase and also the metabolites were being extracted.
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Then, the inhibitor concentration that supports half the maximal charge of inhibition (Ki) and maximal fee of enzyme inhibition (kinact) values were being calculated using the following equation with Enzyme Kinetics software program:
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